胡芬 副教授

详情访问课题组主页：

http://panltlab.org/

研究方向：

细胞信号转导

细胞超分辨成像

科研项目：

基于超分辨成像技术对嘌呤受体介导的小胶质细胞微丝骨架重构的研究（ 31801134 ，国家自然基金青年项目，2019/1/1-2021/12/31），主持。

基于光刻图案化技术的细胞质膜-内质网-线粒体互作的研究（12174208，国家自然基金面上项目，2022/1/1-2025/12/31），参加。

基于超分辨成像技术的人红细胞骨架及膜蛋白CD47特性的研究（11874231，国家自然基金面上项目，2019/1/1-2022/12/31），参加。

昆虫血脑屏障对杀虫剂的阻滞和外排作用及其与棉铃虫抗药性相关机制研究（31871992，国家自然基金面上项目，2019/1/1-2022/12/31 ），参加。

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   详情访问课题组主页：

   http://panltlab.org/

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   1. 1. Fen Hu, Donglan Zhu, Hao Dong, Ping Zhang, Fulin Xing, Wan Li, Rui Yan, Jun Zhou, Ke Xu, Leiting Pan*, Jingjun Xu. Super-resolution microscopy reveals nanoscale architecture and regulation of podosome clusters in primary macrophages. iScience, 2022, 25: 105514.

      2. 杨建宇, 胡芬, 邢福临, 董浩, 侯梦迪, 李任植, 潘雷霆*, 许京军. 结合多次DBSCAN和层次聚类算法的膜蛋白单分子定位超分辨图像分割. 中国激光, 2023.

      3. 胡芬, 林洋, 侯梦迪, 胡浩丰*, 潘雷霆* *, 刘铁根, 许京军. 基于深度学习的细胞骨架图像超分辨重建.光学学报, 2020, 40 (24): 2410001.

      4. Fen Hu, Donglan Zhu, Weiwei Pei, Imshik Lee, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Rhein inhibits ATP-triggered inflammatory responses in rheumatoid rat fibroblast-like synoviocytes. International Immunopharmacology, 2019, 75: 105780.

1. Fen Hu, Yali Zhao, Zhenhai Hui, Fulin Xing, Jianyu Yang, Imshik Lee, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Regulation of intracellular Ca²⁺/CaMKII signaling by TRPV4 membrane translocation during osteoblastic differentiation. Biophysics Reports, 2019, 5(5): 254-263.

2. FulinXing#, Fen Hu#, Jianyu Yang, LeitingPan*, Jingjun Xu. Structural and functional studies of erythrocyte membrane-skeleton by single-cell and single-molecule techniques. Journal of Innovative Optical Health Sciences, 2019, 12: 1830004.

3. Fen Hu, Zhenhai Hui, Wei Wei, Jianyu Yang, Ziyuan Chen, Bu Guo, Fulin Xing, Xinzheng Zhang, Leiting Pan*, Jingjun Xu. Hypotonic stress promotes ATP release, reactive oxygen species production and cell proliferation via TRPV4 activation in rheumatoid arthritis rat synovial fibroblasts. Biochemical and Biophysical Research Communications, 2017, 486 (1): 108-115.

4. 潘雷霆, 胡芬, 张心正, 许京军*. 多色单分子定位超分辨显微成像术的研究. 光学学报, 2017, 37 (8): 0318010.

5. Fen Hu, Fulin Xing, Ge Zhu, Guangxue Xu, Cunbo Li, Junle Qu, Imshik Lee, Leiting Pan*. Rhein antagonizes P2X₇ receptor in rat peritoneal macrophages. Scientific Reports, 2015, 5: 14012.

6. Fen Hu, Leiting Pan*, Kai Zhang, Fulin Xing, Xinyu Wang, Imshik Lee, Xinzheng Zhang, Jingjun Xu. Elevation of extracellular Ca²⁺ induces store-operated calcium entry via calcium-sensing receptors: a pathway contributes to the proliferation of osteoblasts. PLoS One, 2014, 9 (9): e107217.

7. Shuyan Zhu, Yuxiang Wang, Xinyu Wang, Junying Li, Fen Hu*. Emodin inhibits ATP-induced IL-1 beta secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X₇ receptor. Pharmaceutical Biology, 2014, 52 (1): 51-57.

8. Shuyan Zhu, Yuxiang Wang, Leiting Pan, Shuang Yang, Yonglin Sun, Xinyu Wang, Fen Hu*. Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, reactive oxygen species production and cell death in rheumatoid arthritis rat synovial fibroblasts. European Journal of Pharmacology, 2014, 725: 1-9.

9. Fen Hu, Shuang Yang, Dan Zhao, Shuyan Zhu, Yuxiang Wang, Junying Li*. Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-kappa B translocation and ROS production in synoviocytes. Biochemical and Biophysical Research Communications, 2012, 424 (1): 196-200.

10. Fen Hu, Wenwu Sun, Xiaoting Zhao, Zongjie Cui, Wenxiu Yang*. TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization. Biochemical and Biophysical Research Communications, 2008, 369 (4): 989-993.

详情访问课题组主页：

http://panltlab.org/

承担本科生课程：
《生物物理概论》

《医学细胞生物学》

《基础物理实验》

承担研究生课程：

《细胞生物物理》