Leiting Pan has published over 20 papers in scientific journals including Biomaterials, Cell Death Discovery, Scientific Reports and so on, with over 270 citation times. He have taken in charge of projects of National Natural Science Foundation of China, Specialized Research Fund for the Doctoral Program of Higher Education, Fundamental Research Funds for the Central Universities. At present, he acts as the member of Microcirculation and Blood Therapy Committee in Chinese Society of Microcirculation; Youth committee member of Free Radical Medicine and Free Radical Biology Committee, Youth committee member of Biomedical Photonics in the Chinese Optical Society.
Research direction:
Recently, the diffraction limit has been surpassed and lateral imaging resolutions of 20 to 50 nm have been achieved by several super-resolution far-field microscopy techniques including stimulated emission depletion (STED), structured illumination microscopy (SIM), stochastic optical reconstruction microscopy (STORM), photoactivated localization microscopy (PALM). In 2014, Eric Betzig, Stefan Hell and William Moerner won the Nobel Prize due to their contribution in development of ultrahigh resolution fluorescence microscope. Our research aims at understanding how orders emerge in physical and biological systems at the nanometer-scale through 3D-STORM super-resolution microscopy.Specific examples include: (1) nanoscale structure organization of red blood cells. (2)) In vitro cellular processes involving symmetry breaking and emergence of patterns, e.g., cell polarization, motility and development.
Selective Publications:
[1] F Hu, L Pan*, J Xu, et al. Hypotonic stress promotes ATP release, reactive oxygen species production and cell proliferation via TRPV4 activation in rheumatoid arthritis rat synovial fibroblasts. Biochem. Biophys. Res. Commun., 2017, 486: 108~115
[2] L Pan, F Hu, X Zhang, J Xu*. Multi-color Single Molecule Localization Super-Resolution Microscopy. Acta Optica Sinica, 2017, 37: 0318010
[3] F Hu, F Xing, L Pan*, et al. Rhein antagonizes P2X7 receptor in rat peritoneal macrophages. Scientific reports, 2015, 5: 14012
