Individual Resume: Imshik Lee, male, born in South Korea in Sep. 1962, graduated from department of physics of Pusan National University in 1986 with the bachelor's degree, gained the doctoral degree of department of physics of England Bristol University in 1993, and successively worked in England Bristol University (H. H. Wills Physics laboratory), Yanbian University of Science & Technology, Institute of Chemistry, Chinese Academy of Sciences, University of Hong Kong, America Case Western Reserve University, Tokyo Medical and Dental University, etc. Now, he serves as Professor of School of Physics of Nankai University.
Research direction: Nano biological interface mainly involves three aspects: biological interface, physical interface and chemical interface.
Biological interface: Single-molecule dynamics of nano biological interface, including the ligand-receptor interaction (Surf.Sci 2001,491: 433-443);
Chemical interface: Biosimulation and biological model research, designing the biosimulation molecule and representing its interface property on single-molecule level (Biomaterials, 2004,25,1911-1918);
Physical interface: How the physical stimulation transfers to physiological signal
· Transmission of mechanical signal (or changed into force transmission instead of mechanical transmission); The mechanical stimulation directly interacts with the cytoskeleton and sub-membrane molecular, which is related to the physiological function. Due to the dynamic response of living cell, frequency of application and characterization, dynamic stimulation of resting intervals and amplitude, the microfluid porous channel is applied in such method (BBRC 2011,408,350-355); (I can't understand such sentence, it could be changed into the microfluid porous channel technology is applied to research the interaction of mechanical stimulation and cytoskeleton and sub-membrane molecular)
·(Non-) radiation transduction; On the one hand, the light source is very good tool to monitor the bioactivity, on the other hand, the light source could trigger the biological function (BBRC 2010,396,662-666 and CPL 2009.26,1 017102);
· Biological signal model analysis: Biological signal analysis exposing the specific biological functions.
Research topic and academic works:
1. Y Cao, X Wu, X Wang, H Sun, I Lee (2016) Transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel. Archives of Biochemistry and Biophysics. 604:143–151.
2. F Hu, F Xing, G Zhu, G Xu, C Li, J Qu, I Lee, L Pan (2015) Rhein antagonizes P2X7 receptor in rat peritoneal macrophages. Scientific Reports 09/2015; 5:14012. DOI:10.1038/srep14012
3. D Lee, J Lee, I.Lee, (2015) Cell Phone Generated Radio Frequency Electromagnetic Field Effects on the Locomotor Behaviors of the Fishes Poecilia reticulata and Danio rerio, Int. J. Radiation Biology, 91(10): 843-850.( DOI:10.3109/09553002.2015.1062575)
4. M Choe, W. Choe, I.Lee, M Wu, S Liu (2015) Computational Analysis of Mutated AHAS Appeared by Sulfonylurea (SU) Herbicides, Weed Research, 55: 359-369.
5. F Hu, L Pan, K Zhang, F Xing, X Wang, I Lee, X Zhang, J Xu (2014) Elevation of Extracellular Ca2+Induces Store-Operated Calcium Entry via Calcium-Sensing Receptors: A Pathway Contributes to the Proliferation of Osteoblasts. PLoS ONE, 9: e107217
6. G Meng, L Pan, C Li, F Hu, X Shi, I Lee, I Drevensek-Olenik, X Zhang, J Xu, (2014) Temperature-induced Labelling of Fluo-3 AM Selectively Yields Brighter Nucleus in Adherent Cells, BBRC, 443;888-893
7. L Pan, K Song, W Sun, F Hu, I Lee(2013) Nitric oxide induces Ca2+ entry by activating TRPV1-like channel via S-nitrosylation in osteoblasts: an implication of the pathogenesis of inflammation-mediated osteoporosis. Eu.J Pharm, 715; 280-285
